HO-1 Induction by Selaginella tamariscina Extract Inhibits Inflammatory Response in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Figure 1

Effects of STE on the productions of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. (a) Effects of STE on the cell viability. (b) Effects of STE on LPS-induced NO production. (c) Effects of STE on LPS-induced PGE₂ production. (d) Effects of STE on the induction of iNOS and COX-2 by LPS. RAW 264.7 macrophages were pretreated with different concentrations of STE (10, 100, or 300 μg/mL) for 1 h and subsequently exposed to LPS (1 μg/mL) for 24 h, and then protein expressions of iNOS and COX-2 were assessed by western blot. Statistical significance was determined versus vehicle-treated control group ( < 0.001) or LPS-treated group ( < 0.05, < 0.01, and < 0.001).

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