Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats

Figure 1

MB prevents hepatic steatosis in HFD-induced NAFLD. (a) Liver weight and (b) ratio of liver weight to body weight were determined in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). (c) H&E and Oil-Red-O staining were performed using liver tissues in HFD-fed rats after MB treatment for 10 weeks (n=5 per group). Data are mean ± standard error of the mean (SEM). Significance was measured using one-way analysis of variance (ANOVA) followed by Bonferroni’s post hoc test. P < 0.05, P < 0.01, and P < 0.005 vs. Control group; P < 0.05, P < 0.01, and P < 0.001 vs. HFD-fed group. Con: control group; Veh: vehicle-treated group; MB 100 and 200, 100, and 200 mg/kg mulberry extracts-treated groups. HFD: high fat diet; LW: liver weight; BW: body weight; high-mag: high-magnification; low-mag: low magnification. Black scale bar: 50μm; white scale bar: 100μm.

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