Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats

Figure 2

MB ameliorates serum and hepatic lipid levels and hepatic damage markers in HFD-induced NAFLD. Serum (a) TG, (b) TC, (c) LDL, and (d) HDL and (e) hepatic TG, serum (f) ALT, and (g) AST were determined in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). Data are mean ± standard error of the mean (SEM). Significance was measured using one-way analysis of variance (ANOVA) followed by Bonferroni’s post hoc test. P < 0.05, P < 0.01, and P < 0.005 vs. control group; P < 0.05 and P < 0.01 vs. HFD-fed group. Con, control group; Veh, vehicle-treated group; MB 100 and 200, 100, and 200 mg/kg BW mulberry extracts-treated groups. TG: triglycerides; TC: total cholesterol; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase.

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