Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model

Table 2

Inhibitory effects on bidirectional loganin transport in human intestinal Caco-2 cell monolayers. (n = 3).

Inhibitors	Transporter	concentration (μM)	AB	BA	P	Modulatory effect
Control			13.0±0.7	11.7±0.9	0.9	/
Efflux transporters
Verapamil	P-gp	100	11.1±1.7	9.3±1.7	0.84	-
MK 571	MRPs	100	27.2±4.1	3.9±0.2	0.14	+
Indomethacin	MRP2	200	24.7±4.8	4.4±1.1	0.18	+
Benzbromarone	MRP2, MRP3	50	29.5±5.9	6.7±0.9	0.23	+
Apigenin	BCRP	25	30.1±6.2	12.3±2.5	0.41	+
Infflux transporters
Sodium vanadate	Na^+/K^+pump	50	12.3±0.7	9.0±1.1	0.73	-
Cimetidine	OATs	50	11.0±1.5	9.9±2.0	0.9	-

Denotes results significantly different from those of the control experiments (p < 0.05).
Denote results significantly different from those of the control experiments (p < 0.001).
+ Indicates that the inhibitor has significant effect on the loganin transport.