Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis

Figure 4

Histopathological changes (hematoxylin and eosin (H&E) staining) in the knee joint after ChondroT administration in monosodium iodoacetate- (MIA-) induced arthritic rats. Arrows (↓) indicate synovial membrane destruction. Arrow heads (▸) indicate compressed articular cartilage in the control. JC, joint cavity; ACF, articular cartilage of the femur; ACT, articular cartilage of the tibia; BSM, bony spicule within the meniscus; SM, synovial membrane; MH&FC, meniscus of hyaline and fibrocartilage. MIA-induced arthritic rats were orally given water (control), Joins Tab (20 mg/kg), or ChondroT (50, 100 or 200 mg/kg). Scale bars = 500 μm.

(a) Normal

(b) Control

(c) Joins Tab

(d) ChondroT 50

(e) ChondroT 100

(f) ChondroT 200