Research Article
Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice
Figure 2
Cognitive enhancing effects of ginger extracts based on the Morris water maze test. One hour before the test, the mice were orally administered with vehicle or ginger extracts (FGE, 200 mg/kg; DGE, 100 mg/kg; p.o.), and after 30 min, the mice were injected with vehicle or SCO (1 mg/kg, i.p.). (a) Effects of ginger extracts on the SCO-induced spatial memory impairment that was represented by the mean escape latency. Data were presented as mean ± SEM (). Significant difference between the groups: , vehicle-treated control versus SCO group; , SCO group versus ginger extract-treated group in combination with SCO. (b) The representative water maze paths that were selected from each group on the 3rd day of training trials.
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