Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

Figure 4

Protective effect of GIN on the learning and memory impairment induced by SCO in the Y-maze task. One hour before this test, mice were orally administered with vehicle or GIN (25 mg/kg, p.o.), and after 30 min, they were injected with vehicle or SCO (1 mg/kg, i.p.). (a) Effect of GIN on the SCO-decreased spontaneous alternation. (b) Total number of arm entries during the 8-min trials of the Y-maze task. Data were presented as mean ± SEM (). Significant difference between the groups: , vehicle-treated control versus SCO group; , SCO group versus GIN-treated group in combination with SCO.

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