A Pilot Study on Characteristics of Metabolomics and Lipidomics according to Sasang Constitution
Table 2
List of potential plasma biomarkers in three Sasang constitutions.
No.
Tentative metabolites
m/z
Mass error (mDa)
Adduct
Fold change
p value
Pathway
SY/SE
SY/TE
SE/TE
1
Lactic acid
89.0235
M-H
1.49
1.19
0.80
0.090
Propanoate metabolism
2
3-Hydroxybutyric acid
103.0388
-0.69
M-H
0.89
0.61
0.68
0.020
Synthesis and degradation of ketone bodies
3
Valine
118.0737
-13.13
M+H
1.01
0.85
0.85
0.076
Aminoacyl-tRNA biosynthesis Valine, leucine, and isoleucine biosynthesis
4
4-Hydroxybenzaldehyde
121.0285
-0.53
M-H
0.92
0.81
0.75
0.041
Phenylalanine metabolism
5
Benzoic acid
123.0437
-0.94
M+H
1.15
1.17
1.02
0.115
Phenylalanine metabolism
6
Pyrrolidonecarboxylic acid
128.0341
-0.73
M-H
0.98
0.78
0.77
0.068
D-glutamine and D-glutamate metabolism
7
Glutamic acid
130.0376
-12.79
M+H-H2O
0.89
0.79
0.89
0.000
Aminoacyl-tRNA biosynthesis D-Glutamine and D-glutamate metabolism
8
Ornithine
131.0811
-0.96
M-H
0.88
0.86
0.98
0.071
Glutathione metabolism
9
Leucine
132.0883
-14.17
M+H
0.88
0.45
0.40
0.002
Aminoacyl-tRNA biosynthesis Valine, leucine, and isoleucine biosynthesis
10
Glutaric acid
133.0562
6.11
M+H
0.92
0.84
0.92
0.045
Lysine degradation Fatty acid metabolism
11
Adenine
136.0622
-0.12
M+H
0.93
0.89
0.96
0.094
Purine metabolism
12
Phenylacetamide
136.0632
-7.00
M+H
0.85
0.83
0.98
0.084
Phenylalanine metabolism
13
Lysine
145.0953
-2.37
M-H
1.18
1.10
0.93
0.105
Aminoacyl-tRNA biosynthesis
14
Phenyllactic acid
147.0440
-0.63
M-H2O-H
0.88
0.89
0.99
0.038
Phenylalanine and tyrosine metabolism
15
Methionine
148.0421
-1.10
M-H
0.91
0.83
0.92
0.265
Aminoacyl-tRNA biosynthesis
16
Caffeic acid
163.0296
-9.86
M+H-H2O
0.38
0.40
0.94
0.000
Phenylpropanoid biosynthesis
17
Hydroxyphenyllactic acid
163.0390
-0.51
M-H2O-H
0.95
0.80
0.84
0.157
Ubiquinone and other terpenoid-quinone biosynthesis
18
Phenylalanine
164.0701
-1.08
M-H
0.87
0.88
0.99
0.019
Phenylalanine metabolism Aminoacyl-tRNA biosynthesis Phenylalanine, tyrosine, and tryptophan biosynthesis
19
Phenylpyruvic acid
165.0420
-13.20
M+H
0.87
0.85
0.97
0.094
Phenylalanine metabolism Phenylalanine, tyrosine, and tryptophan biosynthesis
20
Hippuric acid
178.0494
-3.80
M-H
0.47
0.68
0.96
0.045
Phenylalanine metabolism
21
Tyrosine
180.0652
-0.93
M-H
0.85
0.88
0.96
0.045
Phenylalanine metabolism Aminoacyl-tRNA biosynthesis Phenylalanine, tyrosine, and tryptophan biosynthesis
22
3-Indolepropionic acid
190.0737
-7.10
M+H
0.36
0.66
0.54
0.247
23
7-Methyluric acid
203.0191
1.05
M+Na-2H
0.89
0.86
0.96
0.024
Caffeine metabolism
24
Indole-3-lactic acid
204.0640
-2.15
M-H
1.07
1.05
0.98
0.07
Tryptophan metabolism
25
Acetylcarnitine
204.1108
-12.79
M+H
0.93
0.84
0.76
0.017
Fatty acid metabolism (acyl carnitine)
26
Propionylcarnitine
218.1265
-12.67
M+H
0.67
0.83
0.80
0.033
Fatty acid metabolism (acyl carnitine)
27
trans-Traumatic acid
227.1272
-1.14
M-H
0.87
0.67
0.77
0.053
28
Melatonin
231.1222
8.82
M-H
0.99
0.58
0.59
0.063
Tryptophan metabolism
29
Hexanoylcarnitine
260.1748
-11.40
M+H
0.75
0.83
0.90
0.042
Fatty acid metabolism (acyl carnitine)
30
Octanoylcarnitine
288.2072
-10.32
M+H
0.68
0.65
0.95
0.033
Fatty acid metabolism (acyl carnitine)
31
5a-Tetrahydrocorticosterone
315.2278
-4.6
M+H-2H2O
0.94
0.84
0.89
0.090
32
Decanoylcarnitine
316.2402
-8.55
M+H
0.72
0.71
0.99
0.071
Fatty acid metabolism (acyl carnitine)
33
Stearoylcarnitine
428.3683
2.29
M+H
1.00
0.85
0.86
0.047
Fatty acid metabolism (acyl carnitine)
SY: Soyangin; TE: Taeeumin; SE: Soeumin. Fold change was calculated by dividing the mean of the peak intensity of each metabolite from each of the two groups. < 0.05; < 0.01; < 0.001.
