A Pilot Study on Characteristics of Metabolomics and Lipidomics according to Sasang Constitution
Table 3
Circulating lipid profiles in the three Sasang constitutions.
No.
Identity
m/z
Mass error (mDa)
Adduct
MS fragments (ESI)
Fold change
p value
Pathway
SY/SE
SY/TE
SE/TE
1
FA (20:0)
311.2904
-4.6
M-H
183
1.18
1.58
1.33
0.116
Lipid metabolism
2
FA (20:4)
303.2241
-8.3
M-H
183
1.50
1.53
1.02
0.049
Arachidonic acid metabolism
3
FA (22:5)
329.2444
-3.7
M-H
183
1.44
1.47
1.02
0.029
Lipid metabolism
4
FA (22:6)
327.2340
1.6
M-H
183
1.88
1.84
0.98
0.005
Lipid metabolism
5
LPC (16:1)
494.3254
0.72
M+H
476, 184, 104
1.26
1.17
0.93
0.026
Lysolipid metabolism
6
LPC (18:0)
568.3622
1.1
M+COOH
508, 283, 183, 153
1.25
1.27
1.02
0.064
Lysolipid metabolism
7
LPE (16:0)
452.2772
-2.00
M-H
255, 214, 196
1.36
1.37
1.01
0.015
Lysolipid metabolism
8
LPE (18:0)
480.3096
5.2
M-H
283, 214, 196
1.28
1.27
1.00
0.054
Lysolipid metabolism
9
LPG (16:0)
507.2762
1.1
M+Na
449, 311, 155
0.93
0.94
1.01
0.088
Lysolipid metabolism
10
LPI (18:0)
599.3170
-2.6
M-H
315, 283, 241
1.23
1.36
1.11
0.044
Lysolipid metabolism
11
PC (32:0)
734.5695
-0.50
M+H
184
1.00
1.18
1.18
0.061
Glycerophospholipid metabolism
12
PC (32:1)
732.5528
1.68
M+H
184
1.46
1.15
0.79
0.040
Glycerophospholipid metabolism
13
PC (33:1)
746.5676
-2.38
M+H
184
1.33
1.10
0.82
0.048
Glycerophospholipid metabolism
14
PC (34:1)
760.5878
2.22
M+H
184
1.23
1.05
0.86
0.033
Glycerophospholipid metabolism
15
PC (36:1)
788.6171
2.97
M+H
184
1.30
1.08
0.83
0.070
Glycerophospholipid metabolism
16
PC (36:5)
780.5535
-0.81
M+H
184
1.63
1.19
0.73
0.072
Glycerophospholipid metabolism
17
PC (36:6)
778.5426
3.94
M+H
184
1.59
1.31
0.82
0.005
Glycerophospholipid metabolism
18
PC (37:6)
792.5567
2.40
M+H
184
1.13
1.04
0.93
0.041
Glycerophospholipid metabolism
19
PC (38:3)
812.6167
-0.18
M+H
184
1.30
1.08
0.83
0.055
Glycerophospholipid metabolism
20
PC (38:5)
808.5840
-1.64
M+H
184
1.35
1.13
0.84
0.084
Glycerophospholipid metabolism
21
PC (38:6)
806.5732
2.44
M+H
184
1.22
1.09
0.89
0.063
Glycerophospholipid metabolism
22
SM (d32:1)
675.5440
-0.13
M+H
184
1.20
1.18
0.98
0.036
Sphingolipid metabolism
23
SM (d34:1)
703.5772
2.37
M+H
184
0.96
1.08
1.13
0.117
Sphingolipid metabolism
24
SM (d35:1)
717.5886
-2.40
M+H
184
1.04
1.16
1.12
0.057
Sphingolipid metabolism
25
SM (d41:1)
801.6847
-0.30
M+H
184
0.91
1.18
1.29
0.052
Sphingolipid metabolism
26
SM (d42:1)
815.7003
-0.30
M+H
184
0.90
1.19
1.33
0.052
Sphingolipid metabolism
27
SM (d43:1)
829.7133
-3.05
M+H
184
0.92
1.19
1.20
0.052
Sphingolipid metabolism
28
1-Deoxysphinganine
286.3099
-0.70
M+H
270
3.59
4.45
1.24
0.009
Sphingolipid metabolism
29
Sphinganine (d17:0)
288.2895
-3.53
M+H
282, 264
1.09
1.46
1.34
0.197
Sphingolipid metabolism
30
Sphinganine (d18:1)
300.2907
-2.44
M+H
310
1.93
1.91
0.99
0.034
Sphingolipid metabolism
31
Sphinganine (d20:1)
310.3120
-0.25
M+H
268
1.44
1.24
0.87
0.040
Sphingolipid metabolism
32
Cholesterol
369.3534
-0.17
M+H
369
0.98
0.94
0.96
0.061
Primary bile acid biosynthesis
33
DG (32:0)
591.4954
-3.40
M+Na
551, 313, 257
0.90
1.17
1.30
0.012
Glycerolipid metabolism
34
TG (50:1)
850.7851
-1.82
M+NH4
603, 551
1.00
1.30
1.30
0.472
Glycerolipid metabolism
35
TG (52:2)
876.8014
4.19
M+NH4
859, 841, 577
1.01
1.20
1.19
0.591
Glycerolipid metabolism
36
TG (54:3)
902.8162
-2.55
M+NH4
867, 603, 339
0.95
1.14
1.19
0.346
Glycerolipid metabolism
Fold change was calculated by dividing the mean of the peak intensity of each metabolite from each of the two groups. SY: Soyangin; TE: Taeeumin; SE: Soeumin. value < 0.05.
