Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Figure 7

Common signaling moleculars association network in different samples in groups on day 21 (correlation coefficients ∈ [−1, −0.8], [0.8, 1]). Common signaling moleculars association network in serum in CFA group (a) or in CFA + MA group (b). Common signaling moleculars association network in ST36 acupoint in CFA group (c) or in CFA + MA group (d). Common signaling moleculars association network in hind foot pad tissue in CFA group (e) or in CFA + MA group (f). Green dots represent neuropeptide or neurotransmitter, pink dots represent hormone, and blue dots represent cytokines. Red lines represents positive correlation between the molecules; blue lines represent negative correlation between the molecules. The thicker line represents greater correlation coefficient; the thinner line represents smaller correlation coefficient.

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