Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Table 2

Common signaling moleculars in serum of CFA group sorted by complex network analysis.

Node strength correlations	Molecular sorting	Node degree	Molecular sorting	Node clustering coefficient	Molecular sorting
5.364006319	IL-1β	6	IL-1β	0	5-HT
5.120790119	IL-6	6	IL-6	0	NPY
4.464794999	IL-1α	5	LH	0	BDNF
4.356832829	LH	5	GH	0	ACTH
4.356832829	GH	5	IL-1α	0	FSH
4.177256544	IL-17	5	IL-5	0	Melatonin
4.09114429	IL-5	5	IL-17	0	PRL
3.6458827	IL-13	4	TSH	0	GRO/KC
3.53653472	TSH	4	T3	0	MIP-3α
3.400877137	IL-12	4	MIP-1α	0	MCP-1
3.364263888	MIP-1α	4	IL-12	0	TNF-α
3.238781977	T3	4	IL-13	0	IL-4
2.605926586	G-CSF	3	IFN-γ	0	IL-10
2.5478666	IFN-γ	3	IL-7	0	GM-CSF
2.524251392	IL-7	3	G-CSF	0	VEGF
1.809686502	Melatonin	2	BDNF	0	EPO
1.728692888	Corticosterone	2	T4	0.166666667	T3
1.711474914	MIP-3α	2	Corticosterone	0.166666667	MIP-1α
1.675529628	RANTES	2	Melatonin	0.2	IL-17
1.638782764	T4	2	MIP-3α	0.266666667	IL-6
1.60762883	BDNF	2	RANTES	0.333333333	IFN-γ
0.918065642	5-HT	1	5-HT	0.333333333	G-CSF
0.865532438	NPY	1	NPY	0.466666667	IL-1β
0.837856344	IL-10	1	FSH	0.5	TSH
0.834973817	IL-4	1	IL-4	0.5	IL-12
0.816730828	EPO	1	IL-10	0.5	IL-5
0.806908726	FSH	1	EPO	0.6	LH
0	ACTH	0	ACTH	0.6	GH
0	PRL	0	PRL	0.6	IL-1α
0	GRO/KC	0	GRO/KC	0.833333333	IL-13
0	MCP-1	0	MCP-1	1	T4
0	TNF-α	0	TNF-α	1	Corticosterone
0	GM-CSF	0	GM-CSF	1	RANTES
0	VEGF	0	VEGF	1	IL-7