Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Table 3

Common signaling moleculars in serum of CFA + MA group sorted by complex network analysis.

Node strength correlations	Molecular sorting	Node degree	Molecular sorting	Node clustering coefficient	Molecular sorting
6.793769656	T3	8	T3	0	5-HT
6.1279229	IL-13	7	IL-13	0	TSH
6.125755358	VEGF	7	VEGF	0	T4
5.345425536	IL-17	6	IL-17	0	ACTH
5.058280921	GM-CSF	6	GM-CSF	0	Corticosterone
4.32642674	IL-1β	5	IL-1β	0	FSH
4.23929481	IL-4	5	IL-4	0	LH
3.653747121	MIP-1α	4	PRL	0	GH
3.536793987	GRO/KC	4	GRO/KC	0	Melatonin
3.520423163	IL-12	4	MIP-1α	0	MIP-3α
3.472198204	IL-7	4	IL-1α	0	RANTES
3.442092944	PRL	4	IL-6	0	IFN-γ
3.437908006	IL-1α	4	TNF-α	0	IL-10
3.343295878	IL-6	4	IL-12	0	G-CSF
3.326627841	TNF-α	4	IL-7	0	EPO
2.790223761	NPY	3	NPY	0.1	IL-4
2.628870992	IL-5	3	BDNF	0.25	T3
2.541007235	BDNF	3	IL-5	0.333333333	BDNF
1.831565026	T4	2	TSH	0.333333333	TNF-α
1.810788756	MCP-1	2	T4	0.333333333	IL-5
1.743848565	Melatonin	2	Melatonin	0.333333333	IL-7
1.73742207	EPO	2	MCP-1	0.333333333	GM-CSF
1.668735302	TSH	2	EPO	0.4	IL-1β
0.860173882	Corticosterone	1	5-HT	0.4	IL-17
0.860173882	IL-10	1	Corticosterone	0.428571429	IL-13
0.831360077	GH	1	GH	0.428571429	VEGF
0.825950091	MIP-3α	1	MIP-3α	0.5	PRL
0.811762933	5-HT	1	IL-10	0.5	GRO/KC
0	ACTH	0	ACTH	0.5	IL-1α
0	FSH	0	FSH	0.666666667	MIP-1α
0	LH	0	LH	0.666666667	IL-6
0	RANTES	0	RANTES	0.666666667	IL-12
0	IFN-γ	0	IFN-γ	1	NPY
0	G-CSF	0	G-CSF	1	MCP-1