Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Table 4

Common signaling moleculars in ST36 acupoint of CFA group sorted by complex network analysis.

Node strength correlations	Molecular sorting	Node degree	Molecular sorting	Node clustering coefficient	Molecular sorting
10.72648569	IL-2	12	IL-2	0	5-HT
9.92879842	IL-12	11	IL-12	0	CGRP
9.756829776	IL-13	11	IL-13	0	SCF
9.692100786	M-CSF	11	M-CSF	0	IGF-1
8.865265516	EPO	10	TNF-α	0	Ach
8.864817973	IL-4	10	IL-4	0	DA
8.756035321	TNF-α	10	EPO	0	LEK
8.190175267	MIP-3α	9	MIP-3α	0	TSH
7.868172048	G-CSF	9	G-CSF	0	T3
6.823300188	IFN-γ	8	IFN-γ	0	Corticosterone
6.281832099	RANTES	7	FSH	0	GHRH
6.133378999	FSH	7	RANTES	0	Melatonin
5.071780915	IL-17	6	IL-17	0	AVP
2.725513459	IL-18	3	VIP	0	SS
2.697281121	CRH	3	CRH	0	IL-1β
2.695360587	VIP	3	GRO/KC	0	IL-6
2.670612454	GRO/KC	3	IL-1α	0	VEGF
2.614138569	IL-10	3	IL-18	0	CRP
2.549577048	IL-1α	3	IL-10	0.333333333	VIP
1.798304838	LEK	2	CGRP	0.333333333	CRH
1.758387897	CGRP	2	NPY	0.333333333	IL-1α
1.757512896	NPY	2	LEK	0.666666667	IL-18
1.711380393	AVP	2	AVP	0.666666667	IL-2
1.704535511	IL-7	2	IL-7	0.666666667	IL-10
0.999281664	5-HT	1	5-HT	0.688888889	EPO
0.999281664	DA	1	SCF	0.745454545	M-CSF
0.870807119	IL-1β	1	IGF-1	0.755555556	TNF-α
0.863267828	Ach	1	Ach	0.761904762	FSH
0.863267828	GHRH	1	DA	0.763636364	IL-12
0.832906845	SCF	1	GHRH	0.763636364	IL-13
0.832906845	IGF-1	1	IL-1β	0.777777778	IL-4
0	TSH	0	TSH	0.805555556	G-CSF
0	T3	0	T3	0.821428571	IFN-γ
0	Corticosterone	0	Corticosterone	0.866666667	IL-17
0	Melatonin	0	Melatonin	0.888888889	MIP-3α
0	SS	0	SS	0.952380952	RANTES
0	IL-6	0	IL-6	1	NPY
0	VEGF	0	VEGF	1	GRO/KC
0	CRP	0	CRP	1	IL-7