Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Table 5

Common signaling moleculars in ST36 acupoint of CFA + MA group sorted by complex network analysis.

Node strength correlations	Molecular sorting	Node degree	Molecular sorting	Node clustering coefficient	Molecular sorting
10.30508457	IFN-γ	11	MIP-3α	0	5-HT
10.20967738	MIP-3α	11	TNF-α	0	Ach
10.14565087	TNF-α	11	IL-2	0	DA
10.14143505	EPO	11	IFN-γ	0	TSH
9.984491306	IL-2	11	IL-17	0	T3
9.835412633	IL-17	11	EPO	0	Corticosterone
9.586116688	IL-4	10	RANTES	0	FSH
9.58555599	IL-13	10	IL-12	0	GHRH
9.496416209	IL-12	10	IL-4	0	Melatonin
9.324953981	G-CSF	10	IL-13	0	IL-1α
9.322535406	RANTES	10	G-CSF	0	IL-1β
5.816288172	M-CSF	7	M-CSF	0	IL-6
4.447630823	IL-7	5	LEK	0	CRP
4.428353692	LEK	5	CRH	0.166666667	NPY
4.330583532	AVP	5	AVP	0.3	CRH
4.254168273	CRH	5	IL-7	0.333333333	VIP
3.726312879	CGRP	4	CGRP	0.333333333	VEGF
3.665515648	GRO/KC	4	NPY	0.4	IL-7
3.631586867	IGF-1	4	IGF-1	0.476190476	M-CSF
3.626838652	IL-10	4	GRO/KC	0.5	AVP
3.3417145	NPY	4	IL-10	0.5	IL-10
2.863080058	IL-18	3	SCF	0.6	LEK
2.733155888	SCF	3	VIP	0.666666667	GRO/KC
2.612860185	VIP	3	IL-18	0.818181818	IL-17
2.432869853	VEGF	3	VEGF	0.833333333	CGRP
1.777426407	Ach	2	Ach	0.833333333	IGF-1
1.745137778	SS	2	SS	0.890909091	MIP-3α
0.995761145	5-HT	1	5-HT	0.890909091	TNF-α
0.995761145	DA	1	DA	0.890909091	IL-2
0.909867657	GHRH	1	GHRH	0.890909091	IFN-γ
0.832121031	IL-1β	1	Melatonin	0.890909091	EPO
0.831984815	Melatonin	1	IL-1β	1	SCF
0	TSH	0	TSH	1	SS
0	T3	0	T3	1	RANTES
0	Corticosterone	0	Corticosterone	1	IL-18
0	FSH	0	FSH	1	IL-12
0	IL-1α	0	IL-1α	1	IL-4
0	IL-6	0	IL-6	1	IL-13
0	CRP	0	CRP	1	G-CSF