Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Table 6

Common signaling moleculars in hind footpad tissue of CFA group sorted by complex network analysis.

Node strength correlations	Molecular sorting	Node degree	Molecular sorting	Node clustering coefficient	Molecular sorting
19.10661085	EPO	20	Substance P	0.5	TSH
19.10443745	Substance P	20	5-HT	0.5	IL-10
19.09503987	IL-1α	20	IGF-1	0.588235294	Neurotensin
19.08824776	IL-6	20	LEK	0.607142857	CRH
19.07123329	IGF-1	20	Melatonin	0.617647059	Oxytocin
19.06447235	5-HT	20	IL-1α	0.631578947	Melatonin
18.50160671	LEK	20	IL-6	0.666666667	Corticosterone
18.29600965	PRL	20	EPO	0.692307692	α-MSH
18.29571712	IL-2	19	β-Endorphin	0.705263158	LEK
18.27023516	FSH	19	DA	0.772727273	NPY
18.25430456	DA	19	FSH	0.772727273	T3
18.25266497	Melatonin	19	PRL	0.782051282	CGRP
18.0674304	M-CSF	19	SS	0.8	VIP
18.04781731	β-Endorphin	19	RANTES	0.8	AVP
17.94864817	SS	19	IL-2	0.807017544	SS
17.94592524	RANTES	19	M-CSF	0.807017544	RANTES
16.95153766	GH	18	GH	0.831578947	5-HT
15.47470248	Oxytocin	17	Neurotensin	0.831578947	IGF-1
15.40534815	Neurotensin	17	Oxytocin	0.831578947	IL-1α
14.93565299	Ach	16	BDNF	0.831578947	IL-6
14.9351783	BDNF	16	Ach	0.836363636	SCF
12.16893349	α-MSH	13	CGRP	0.836363636	CRP
11.68002365	CGRP	13	α-MSH	0.842105263	Substance P
11.2866825	NPY	12	NPY	0.842105263	β-Endorphin
11.27743293	T3	12	T3	0.842105263	M-CSF
10.44668172	CRP	11	SCF	0.842105263	EPO
10.43829458	SCF	11	CRP	0.85620915	GH
9.545156525	GHRH	10	VIP	0.883040936	DA
9.391637867	AVP	10	GHRH	0.883040936	FSH
9.373485793	VIP	10	AVP	0.883040936	PRL
8.148967846	Corticosterone	9	Corticosterone	0.883040936	IL-2
7.229380481	CRH	8	CRH	0.883333333	BDNF
4.484931739	TSH	5	TSH	0.883333333	Ach
3.693908813	IL-10	4	IL-10	0.888888889	GHRH