Applying Statistical and Complex Network Methods to Explore the Key Signaling Molecules of Acupuncture Regulating Neuroendocrine-Immune Network

Table 7

Common signaling moleculars in hind foot pad tissue of CFA + MA group sorted by complex network analysis.

Node strength correlations	Molecular sorting	Node degree	Molecular sorting	Node clustering coefficient	Molecular sorting
18.40435568	Substance P	20	Substance P	0.5	DA
18.40150748	Neurotensin	20	Neurotensin	0.642857143	FSH
17.63806473	Oxytocin	19	Oxytocin	0.666666667	LEK
17.60762122	PRL	19	PRL	0.69005848	Oxytocin
16.88856039	GHRH	18	NPY	0.692810458	β-Endorphin
16.83720135	NPY	18	β-Endorphin	0.7	Substance P
16.79938918	CRP	18	GHRH	0.7	Neurotensin
16.69891691	β-Endorphin	18	CRP	0.705128205	IL-6
16.00352427	VIP	17	5-HT	0.705882353	5-HT
15.77571079	IL-2	17	CGRP	0.705882353	Corticosterone
15.69108923	CGRP	17	VIP	0.713235294	CGRP
15.65507789	Corticosterone	17	Corticosterone	0.713450292	PRL
15.6462691	5-HT	17	IL-2	0.714285714	RANTES
15.20421904	IGF-1	16	IGF-1	0.720588235	IL-2
15.157233	α-MSH	16	α-MSH	0.722222222	Ach
15.15132027	AVP	16	AVP	0.725490196	GHRH
15.04667388	IL-10	16	IL-10	0.727272727	GH
13.98760052	SS	15	LEK	0.736263736	CRH
13.80904047	LEK	15	SS	0.738562092	NPY
13.77891314	M-CSF	15	M-CSF	0.75	BDNF
13.1712101	TSH	14	TSH	0.752380952	SS
13.1430236	CRH	14	CRH	0.758169935	CRP
13.09659812	RANTES	14	Melatonin	0.758241758	TSH
12.88753949	Melatonin	14	RANTES	0.785714286	IL-1α
11.9691417	IL-6	13	T3	0.79047619	M-CSF
11.905127	T3	13	IL-6	0.794117647	VIP
11.89354354	EPO	13	EPO	0.813186813	Melatonin
11.08226901	GH	12	GH	0.816666667	α-MSH
8.51846022	SCF	9	SCF	0.816666667	AVP
8.373711747	BDNF	9	BDNF	0.816666667	IL-10
8.142776395	Ach	9	Ach	0.833333333	SCF
7.508261048	IL-1α	8	DA	0.833333333	IGF-1
7.278849151	FSH	8	FSH	0.833333333	T3
7.056443065	DA	8	IL-1α	0.833333333	EPO