Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial

Table 3

Adverse events in the study population.

	Intervention (%)				Control (%)
	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
Cutaneous
Allergy	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)
Infections	0(0.00)	0(0.00)	0(0.00)	0(0.00)	1(3.85)	0(0.00)	0(0.00)	0(0.00)
Bleeding	1(4.35)	0(0.00)	0(0.00)	0(0.00)	1(3.85)	1(3.85)	0(0.00)	0(0.00)
Dry skin	0(0.00)	1(4.35)	0(0.00)	0(0.00)	1(3.85)	0(0.00)	0(0.00)	0(0.00)
Skin tenderness	1(4.35)	1(4.35)	0(0.00)	0(0.00)	2(7.69)	0(0.00)	0(0.00)	0(0.00)
Non-cutaneous
Renal disorders	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)
Liver disorders	1(4.35)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	1(3.85)	0(0.00)	0(0.00)