Aster glehni Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPARδ-AMPK Pathway

Figure 8

Schematic diagram for the functional mechanism of Aster glehni extract in keratinocytes. The effects of Aster glehni on skin barrier protection are mainly mediated via the sequential regulation of TRPV4→ PPARδ→ p-AMPK→ skin barrier constituting elements; also it is partly done by anti-inflammation through the inhibition of TNFα. Meaning of symbols: arrow means activation, up and horizontal line means inhibition, and double vertical line means blocking.