| | Models | Extracts/compounds | Methods | Mode of administration | Pharmacokinetic parameters | Ref. |
| | Rabbits | Verticine | LC-MS/MS | ig administration
iv administration | A two-compartment model, = 48.31±7.40 ng/mL, = 270.08±80.17 ng/(mL/h), =6.38±3.11 h
A three-compartment model, = 84.39±15.39 ng/mL, =50.72±14.02 ng/(mL/h), = 2.19±1.07 h | [2] |
| Sprague-Dawley female rats
Sprague-Dawley male rats | 4.25 g/kg Fritillaria thunbergii Miq. Extract | LC-MS/MS | a single oral administration | = 43.7±22.7 ng/mL, =1.5±0.7h, =4.2±2.0 h, = 214.2±84.6 ng/(mL/h), = 214.3±84.5 ng/(mL/h), CL/F= 128.9±32.6 L/kg/h, V/F= 781.3±305.6 L/kg
= 57.6±21.6 ng/mL, =2.9±1.7 h, =6.2±1.9 h, = 662.4±277.9 ng/(mL/h), = 665.3±213.3 ng/(mL/h), CL/F= 41.5±20.1 L/h/kg, V/F= 374.1±186.2 L/kg | [3] |
| | Sprague-Dawley Rats | Fritillaria thunbergii Miq. Extract (0.45 g/kg body weight) | RRLC-MS/MS | gastric gavage | A two-compartment model, = 3.671±0.876 μg/L, =32.5±11.292 min, = 29.269±24.156 min, =162.897±30.669 min, = 628.568±100.99 μg/(L min), = 630.875±102.136 μg/(L min), CL/F= 0.423±0.075 L/min/kg, V1/F= 40.832±17.616 L/kg | [4] |
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