Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA<sub>1</sub>

<div>Berberine potentially binds to LPA<sub>1</sub>, as detected by molecular docking. (a) The structure of berberine. (b) The schematic diagram illustrating the combination of berberine with LPA<sub>1</sub>. (c) Berberine potentially binds to Lys39A of LPA<sub>1</sub> by two hydrogen bonds and to Arg124A by the hydrophobic force. LPA<sub>1,</sub> lysophosphatidic acid receptor 1; Arg, arginine; and Lys, lysine.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA<sub>1</sub> 

Evidence-Based Complementary and Alternative Medicine

Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1

Figure 4

Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA₁