Therapeutic Efficiency of an External Chinese Herbal Formula of Mammary Precancerous Lesions by BATMAN-TCM Online Bioinformatics Analysis Tool and Experimental Validation

Figure 10

Effects of RYNXC on protein expression of ER-α, PR, EGFR, COX2, and Src in breast precancerous lesion model rats. (a) Western-blot assays of key protein expression in normal rats or breast precancerous lesion model rats without treatment or continuously treated with blank matrix, TAM, high dose RYNXC, and low dose RYNXC for 14 weeks.(b) Relative protein expression of ER-α, PR, EGFR, COX2, and Src in (a). P<0.05, disease model, blank matrix, TAM, or RYNXC (high or low dose) rats versus normal control rats; ^▲P<0.05, normal, blank matrix, TAM, or RYNXC (high or low dose) rats versus disease model rats (n=10 in each group).

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