Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model

Figure 4

Effect of daily oral YKS on bone cancer pain. Mice injected by 4T1 cells and uninjected control mice were p.o. administered with 10 mg of YKS or saline once daily for 7 days. Weight bearing (a) and surface resting (b) on right and left hind paws were measured on the indicated days with the DWB device as described in the legend for Figure 2. The values shown are the mean ± SD (n = 6). Student’s t-test was applied for statistical analysis. P < 0.05 compared to saline administration.

(a)

(b)