Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy

Figure 5

Effect of DSS on renal fibrosis associated with hypoxia. (a) Representative confocal fluorescent images of the kidney sample with HIF-1α (red) and DAPI (blue). (b) Protein levels of BMP-7, TGF-β1, HIF-1α in kidney tissue were determined by western blotting (n=3). (c) Quantification of protein levels. Results are expressed as mean SEM. versus Sham; ^#P<0.05, ^###P<0.001 versus UUO only. UUO, unilateral ureteral obstruction; Bena, benazepril, 1.7 mg/kg/day by oral gavage for 4 weeks; DSS, Danggui Shaoyao San, 9.4g/kg/day by oral gavage for 4 weeks.

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