In Vitro Antiatherothrombotic Effects of Extracts from Berberis Vulgaris L., Teucrium Polium L., and Orthosiphon Stamineus Benth
Table 1
Inhibition of platelet aggregation (%) in human whole blood with BVPE, BVAE, TPPE, and TPAE using platelet agonists of collagen (2 μg/ml), ADP (10 μM), and AA (0.5 μM).
Sample
Concentration
Inhibition of Platelet Aggregation (%)
(μg/ml)
Collagen
ADP
AA
BVPE
12.5
40.4 ± 3.4
23.8 ± 3.9
49.6 ± 3.4
25
45.8 ± 2.8
26.7 ± 2.6
52.0 ± 3.1
50
53.7 ± 6.9
35.9 ± 3.1
52.6 ± 2.6
BVAE
12.5
39.6 ± 3.1
34.1 ± 3.7
49.3 ± 2.8
25
44.4 ± 3.6
36.3 ± 3.9
55.5 ± 3.5
50
47.1 ± 3.6
48.9 ± 2.8
60.9 ± 2.9
TPPE
12.5
31.6 ± 3.2
26.5 ± 4.3
36.2 ± 2.2
25
39.2 ± 4.6
35.7 ± 4.6
43.7 ± 3.8
50
42.2 ± 4.4
48.4 ± 4.1
54.3 ± 4.5
TPAE
12.5
25.8 ± 4.1
11.1 ± 3.9
42.0 ± 4.5
25
32.9 ± 4.1
26.7 ± 3.5
44.1 ± 3.6
50
36.3 ± 4.4
44.4 ± 3.9
45.6 ± 3.3
Aspirin
30
76 ± 3.3
46.7 ± 4.2
100
Aspirin was used as a positive control. Results were expressed as mean ± SEM. BVAE showed highest inhibition in AA-induced platelet aggregation. <0.05 as compared with respective control.
