Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Figure 3

TUNEL staining showing enhanced apoptosis of neurons in the hippocampus of DD rats. (a) Images of TUNEL staining (×400). Co: control group; Di: diabetes model group; De-like: depression-like model group; DD: DD model group; LY+DD: LY341495+DD group. (b) Quantification of TUNEL-positive cell number. Results are presented as mean ± standard deviation (n=6 rats/group). p < 0.05, p < 0.01 vs. control; ^#p < 0.05, ^##p < 0.01 vs. diabetes group; ^Δp < 0.05, ^ΔΔp < 0.01 vs. depression group; ^∧p < 0.05, ^∧∧p < 0.01 vs. DD group.

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