Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Figure 5

Changes in immunoexpression of caspase-3, mGluR2/3, and ERK among model groups. (a) Images of immunohistochemical staining (×400). (b) Quantification of immunoexpression by integral optical density (IOD). Results are presented as mean ± standard deviation (n=6 rats/group). A: control group; B: diabetes model group; C: depression-like model group; D: DD model group; E: LY341495+DD. p < 0.05, p < 0.01 vs. Control; ^#p < 0.05, ^##p < 0.01 vs. diabetes group; ^Δp < 0.05, ^ΔΔp < 0.01 vs. depression group; ^∧p < 0.05, ^∧∧p < 0.01 vs. DD group.

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