Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats

Figure 4

Effect of ginsenoside Re on myocardial fibrosis and hydroxyproline content in isoproterenol-induced myocardial fibrosis and heart failure in rats. (a) Representative photomicrographs of Sirius Red staining of rat hearts. Collagen fibers were stained red (black arrows) and myocardial tissues were stained yellow (n = 3), (b) bar graph of myocardial fibrosis (percentage of fibrotic tissue in hearts), and (c) bar graph of hydroxyproline content. Control group: n = 8; isoproterenol group: n = 6; ginsenoside Re (5 mg/kg) group: n = 6; ginsenoside Re (20 mg/kg) group: n = 7. Data are the mean ± SD. ^##P < 0.01 compared with the control group. < 0.05 or < 0.01 compared with the isoproterenol group. Bar=100 μm.

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