Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

Figure 3

Mean concentration-time profiles of the administered IRN and generated RN in the rat plasma (a), brain (b) and CSF (c) after oral administration of IRN at 20 mg/kg. Concentration-time profiles of the administered RN and generated IRN in the rat plasma (d), brain (e) and CSF (f) after oral administration of RN at 20 mg/kg. (Semi-logarithmic plots were inserted in the corresponding figures).

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