Research Article

Antileishmanial Evaluation of the Leaf Latex of Aloe macrocarpa, Aloin A/B, and Its Semisynthetic Derivatives against Two Leishmania Species

Scheme 1

A: acid hydrolysis of components of the leaf latex of Aloe macrocarpa to aloin A/B; B: oxidative hydrolysis of aloin A/B (1) to aloe-emodin (2); C: further oxidation of aloe-emodin to rhein (3).