Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats
Figure 1
Histopathology of kidney. (a) Section of kidney from control group rats showing the normal appearance of glomerulus (GL) and renal tubules (T) including proximal convoluted tubules (PCT) and distal convoluted tubules (DCT) and interstitium (I); (b) sections of the rats treated with PCM alone showed severe tubular degeneration, with wide lumina (L), damaged glomeruli (GL), and interstitial vascular congestion and epithelial degeneration (I); (c) sections of rats treated with EL 100mg/kg showed significant nephroprotection with moderate degenerative changes in the glomeruli (GL) and tubules (T); (d) sections of rats treated with EL 200 mg/kg showed significant nephroprotection with minimal degenerative changes in the glomeruli (GL) and tubules (T)s; (e) sections of rats treated with 400mg/kg showed near normal appearance of glomeruli (GL) and interstitium and tubules (T) including PCT and DCT. H & E stain: 40x.