Systems-Pharmacology-Based Identification of Antitumor Necrosis Factor Effect in Mimeng Flower Decoction for the Treatment of Diabetic Retinopathy

Table 2

Topological analysis of the compound-target-disease network.

Gene symbol	Gene name	Degree	Closeness	Betweenness
TNF	Tumor necrosis factor	18	0.91	0.15
NOS3	Nitric oxide synthase 3	15	0.80	0.05
PTGS2	Prostaglandin-endoperoxide synthase 2	15	0.80	0.05
MMP9	Matrix metallopeptidase 9	14	0.74	0.05
PPARG	Peroxisome proliferator-activated receptor-gamma	14	0.74	0.03
CXCL8	C-X-C motif chemokine ligand 8	13	0.71	0.02
ICAM1	Intercellular adhesion molecule 1	12	0.69	0.02
CRP	C-reactive protein	12	0.69	0.02
TGFB1	Transforming growth factor beta 1	12	0.67	0.01
SOD1	Superoxide dismutase 1	11	0.69	0.06
HIF1A	Hypoxia-inducible factor 1 subunit alpha	11	0.67	0.01
VCAM1	Vascular cell adhesion molecule 1	11	0.65	0.00
NFE2L2	Nuclear factor, erythroid 2 like 2	9	0.65	0.04
MMP3	Matrix metallopeptidase 3	9	0.61	0.00
F3	Coagulation factor III, tissue factor	8	0.59	0.00
AKR1B1	Aldo-keto reductase family 1 member B	6	0.59	0.07
PON1	Paraoxonase 1	6	0.59	0.02
PPARGC1A	PPARG coactivator 1 alpha	6	0.57	0.00
GSTM1	Glutathione S-transferase mu 1	4	0.48	0.02
ALDH2	Aldehyde dehydrogenase 2 family member	2	0.41	0.00
CTSD	Cathepsin D	2	0.50	0.00