Acute and Subacute Toxicity of Methanol Extract of Syzygium guineense Leaves on the Histology of the Liver and Kidney and Biochemical Compositions of Blood in Rats

Table 5

Effect of 80% methanol extract of leaves of S. guineense on biochemical parameters in subacute toxicity study.

Biochemical parameters	Dose	Mean	95% Confidence interval for mean		P value
			Lower Bound	Upper Bound
AST (IU/L)	Controls	287.83	213.56	362.10	.181
	500mg/kg	325.83	296.77	354.90
	1500mg/kg	257.50	181.82	333.18
ALT (IU/L)	Controls	198.17	170.56	225.78	.257
	500mg/kg	228.50	181.83	275.17
	1500mg/kg	193.67	150.80	236.54
Urea (mg/dl)	Controls	51.33	46.25	56.42	.055
	500mg/kg	58.00	54.62	61.38
	1500mg/kg	60.17	51.15	69.18
Creatinine (mg/dl)	Controls	.72	.64	.80	.307
	500mg/kg	.78	.68	.89
	1500mg/kg	.80	.69	.92
Total Protein (mg/dl)	Controls	6.32	5.55	7.09	.891
	500mg/kg	6.28	5.73	6.84
	1500mg/kg	6.43	6.04	6.83
Glucose (mg/dl)	Controls	80.83	74.22	87.45
	500mg/kg	53.83	49.72	57.95	.0001
	1500mg/kg	61.83	51.06	72.60	.013

One way ANOVA, n = 6/group.
Post hoc analysis.