Effect of Kangxianling Decoction on Expression of TGF-β1/Smads and Extracellular Matrix Deposition

Figure 4

KXL alleviated 5/6 nephrectomy operation induced renal fibrosis by downregulation of TGF-β1, Smad2/3, CTGF, Collagen I, and Collagen III and upregulation of Smad7. (a) Representative western blot images demonstrating the expression of TGF-β1, Smad2/3, Smad7, CTGF, Collagen I, and Collagen III in kidney tissue from the control, sham, model, KXL, and LP groups. (b) The ratio of TGF-β1, Smad2/3, Smad7, CTGF, Collagen I, and Collagen III expression levels to GAPDH. Data were expressed as the mean ± standard error of mean. P < 0.01 compared with control group and sham group; #P < 0.05 and ##P < 0.01 compared with model group.

(a)

(b)