Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of Persea americana and Their Effectiveness in Type 2 Diabetic Rats
Table 2
Biochemical parameters of type 2 diabetic rats after 28 consecutive days of treatment.
Biochemical parameters
Groups
NDC (n = 5)
DC (n = 6)
GLIB (10 mg/kg) (n = 6)
Variation (%)
AE (100 mg/kg) (n = 7)
Variation (%)
EE (100 mg/kg) (n = 7)
Variation (%)
ME (100 mg/kg) (n = 7)
Variation (%)
AST (U/L)
172.52 ± 18.38
477.18 ± 144.23
506.08 ± 112.20
6.1
300.70 ± 111.19
−12.6
410.23 ± 115.14
−14.0
448.46 ± 134.45
−31.0
ALT (U/L)
87.84 ± 17.49
162.35 ± 33.88
104.37 ± 13.67
−35.7
209.11 ± 64.33
28.8
142.14 ± 35.45
−12.4
150.257 ± 33.90
−7.4
AlkP (U/L)
389.28 ± 30.96
838.78 ± 196.46
642.88 ± 226.23
−23.4
940.69 ± 176.21
12.1
524.16 ± 170.58
−37.5
443.29 ± 51.12
−47.2
BUN (mg/L)
29.40 ± 1.97
66.00 ± 12.42
65.17 ± 18.52
−1.3
43.29 ± 7.95
−34.4
32.86 ± 5.30
−50.2
28.29 ± 1.64
−57.1
CREA (mg/L)
2.83 ± 0.67
4.18 ± 0.19
3.45 ± 0.35
−17.5
4.04 ± 0.25
−3.4
3.49 ± 0.10
−16.7
3.67 ± 0.15
−12.2
UA (mg/L)
22.32 ± 1.71
26.67 ± 4.46
31.05 ± 3.43
16.4
33.29 ± 7.27
24.8
19.99 ± 2.71
−25.1
27.39 ± 2.89
2.7
Na+ (mmol/L)
143.40 ± 0.51
143.17 ± 1.33
136.00 ± 0.63
−5.0
143.43 ± 1.63
0.2
142.39 ± 1.14
−0.5
145.43 ± 1.17
1.6
K+ (mmol/L)
6.48 ± 0.49
7.29 ± 0.57
7.41 ± 0.24
1.7
7.23 ± 1.00
−0.8
6.30 ± 0.23
−13.5
7.27 ± 0.45
−0.2
Cl− (mmol/L)
103.20 ± 1.53
103.33 ± 0.88
100.33 ± 0.42
−2.9
102.86 ± 1.10
−0.5
103.44 ± 1.27
0.1
107.57 ± 1.41
4.1
Ca2+ (mg/L)
104.36 ± 2.21
99.65 ± 5.39
95.13 ± 5.54
−4.5
102.79 ± 4.35
3.1
108.34 ± 2.92
8.7
111.41 ± 2.52
11.8
AIP (LDL/HDL)
0.673 ± 0.239
1.786 ± 0.395
1.121 ± 0.342
−43.2
0.783 ± 0.202
−26.2
0.542 ± 0.175
−38.1
0.747 ± 0.259
−45.0
AST: aspartate aminotransferase; ALT: alanine aminotransferase; BUN: blood urea nitrogen; AlkP: alkaline phosphatase, CREA: creatinine; UA: uric acid; Na+: sodium ion; K+: potassium ion; Cl−: chloride ion, Ca2+: calcium ion, AIP: atherogenic index of plasma. NDC: nondiabetic Control treated with vehicle; DC: diabetic control treated with vehicle; GLIB: group treated with glibenclamide, 10 mg/kg; AE: group treated with aqueous extract, 100 mg/kg; EE: group treated with ethanol extract, 100 mg/kg; ME: group treated with methanol extract, 100 mg/kg. The values are expressed as mean ± SEM (n = 5–7). Statistical significance vs. DC ().
