The Effect of Ginsenoside RB1, Diazoxide, and 5-Hydroxydecanoate on Hypoxia-Reoxygenation Injury of H9C2 Cardiomyocytes

Figure 10

Effect of GS-Rb1 on the opening of mPTP in H9c2 cells. Column A, control H9c2 cells not subjected to HR. Column B, H9c2 cells subjected to HR without pretreatment showed increased mPTP opening compared with nontreated cells. Column C, pretreatment with GS-Rb1 protected H9c2 cells from mPTP opening during HR. Column D, simultaneous pretreatment with 5-HD prevented GS-Rb1 from protecting H9c2 cells against mPTP opening during HR. Column E, pretreatment with diazoxide reduced the mPTP opening of H9c2 cells during HR. HR, hypoxia-reoxygenation; GS-Rb1, ginsenoside Rb1; 5-HD, 5-hydroxydecanoate.