Recognition and Optimization of Ingredients Treating Nitroglycerin-Induced Migraine Rats from Wuzhuyu Decoction

Table 4

The regression coefficients of partial least squares regression between the contents of the nine ingredients in WZYD and the values of pharmacodynamic indices and the comprehensive effect between decoction spectrum, absorption spectrum, and pharmacodynamic effects.

Ingredient	Unnormalized coefficients					Comprehensive effect
	NE	5-HT	5-HIAA	NO-p	NO-b	Decoction spectra-effects	Absorption spectra-effects
Lcs	68.92	283.04	-16.91	-36.91	-2.87	21.77	-2.33
Rg1	4.24	-162.32	-27.68	12.66	-1.46	-31.25	-5.64
Re	-38.73	8.31	-6.16	26.65	0.47	5.69	5.85
Rb1	21.08	135.46	9.91	11.03	0.34	11.82	6.01
Rv	7.69	-537.48	26.35	35.12	0.34	-75.33	1.82
Li	-10.35	-19.46	-2.88	1.41	0.04	-0.49	5.40
6-Gi	73.89	167.61	65.15	35.72	1.48	7.60	6.73
Ev	-35.77	524.10	20.20	12.37	0.35	82.31	-71.36
Ru	-14.12	345.56	203.52	-501.13	11.40	193.08	36.92

Notes: the cost indices including NE, NO-p, and NO-b that needed to change the sign.