Development of a MD-LC-MS/MS Method to Analyze 3 Bioactive Compounds in Huoxuezhitong Rubber Patch and Application to a Pharmacokinetic Study in Rats

Table 2

The matrix effects of QC samples at three concentrations (n=6).

Concentration (ng/mL)	Matrix effect
	Mean ± SD(ng/mL)	RSD (%)
Paeonol
1	101.65±10.36	10.19
20	90.31±3.03	3.35
80	96.81±4.33	4.48
Eugenol
1	97.59±13.23	13.55
20	108.63±10.23	9.42
80	109.56±5.60	5.11
Piperine
0.003	93.35±0.88	0.94
0.1	99.21±0.72	0.73
4	100.2±0.17	0.17