Rediscovering Medicinal Amazonian Aromatic Plants: Piper carpunya (Piperaceae) Essential Oil as Paradigmatic Study

Table 3

Synergistic effect of P. carpunya EO employing fluconazole as synthetic active drug against Candida sp.

	FICindex MIC Findex MCF		EO		FLU
	(EO+FLU) (EO+FLU)		MIC	MFC	MIC	MFC
C. albicans (AIDS6)	(391+4)	(391+4)	1562	1562	128	128
C. glabrata (FLU 43976)	(391+4)	(391+4)	1562	1562	32	32
C. albicans (ATCC 24433)	1.063; (781+2)	0.016; (1562+0.5)	781	1562	32	32

FICindex: fractional inhibitory concentration index; ≤ 0.5 means the presence of synergistic effect; 0.5≤FIC ≤2 means additive or indifferent effect; > 2 means antagonistic effect[9, 10].
Values displaying a synergistic effect.
Concentration in g/mL of EO and FLU, respectively, corresponding to FICindex.
MIC: Minimum Inhibitory Concentration (g/mL); MFC: Minimum Fungicidal Concentration (g/mL).
EO: P. carpunya EO; FLU: fluconazole.