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| No | Herb formulae/medical prescription | Medicinal use | Type of zebrafish | Toxic effects | References | Toxicity compared with other assays |
| Survival/mortality | Teratogenic and other toxic effects |
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| 1 | Chinese medical prescriptions (CMPs)
Si jun Zi Tang (SJZT)
Liu jun Zi Tang (LJZT)
Shenling Baizhu (SLBS) | Prescribed for poor appetite, loose stool, abdominal distension, lassitude, prolapsed anus, shortness of breath, dysphasia, and spontaneous sweating | Transgenic zebrafish line Tg (wt1b:EGFP) | All three CMPs exhibited 93.3 ± 6.7% to 100 ± 0.0% of survival at 48 hpf after exposure to 25 and 250 ng/mL. The survival rates decreased to 53.3 ± 8.1% to 86.7 ± 6.7% when exposed to 1250 ng/mL of all CMPs | The % of kidney malformation reported for different concentration
25 ng/mL, 0–10%;
250 ng/mL, 0–60%; 1,250 ng/mL, 80–100%)
Embryonic zebrafish kidney was more sensitive to SLBS | [20] | Not compared |
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| 2 | Chinese patent medicine (CPM), compound Danshen Tablet (CDT), Angong Niuhuang Pill (ANP), and Lidan Paishi Tablet (LPT) | Used to treat heart diseases, central nervous system diseases, and gallbladder diseases | AB strain zebrafish | The LC50 values for CDT, ANP, and LPT were calculated as 417, 596, and 380 μg/mL, respectively. | EC50 values of teratogenic effects were 351, 793, and 220 μg/mL for CDT, ANP, and LPT. The tail bending and cardiac oedema were the main teratogenic effects. CDT and LPT were cardiotoxic | [21] | Not compared |
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