Pilose Antler Extracts (PAEs) Protect against Neurodegeneration in 6-OHDA-Induced Parkinson’s Disease Rat Models

Figure 5

PAEs upregulated the levels of glutamate and GABA in the CSF and striatum of PD rats model. (a) 6-OHDA enhanced remarkably glutamate and GABA in CSF of rats, while 60 mg/kg·d, 180 mg/kg·d PAEs administration restore glutamate and GABA to nomal level, but Madopar had no significantly changed. (b) 6-OHDA increased glutamate and GABA in striatum of rats, while 60 mg/kg·d and 180 mg/kg·d PAEs administration significantly decreased glutamate level (p<0.05 versus model, p<0.01 versus model).

(a)

(b)