Identified the Synergistic Mechanism of Drynariae Rhizoma for Treating Fracture Based on Network Pharmacology

Table 6

The protein class corresponding to potential targets for treating fracture from main active ingredients of Drynariae Rhizoma.

No.	Gene name	Protein class
1	ADH1B	Oxidoreductase
2	ADH1C	Oxidoreductase
3	ADH7	Oxidoreductase
4	AGXT	Transferase
5	AKT1	Calcium-binding protein; kinase; transfer/carrier protein; transferase
6	AKT2	Calcium-binding protein; kinase; transfer/carrier protein; transferase
7	ALPP	Hydrolase; phosphatase
8	ANG	None
9	ANXA5	None
10	AR	Nucleic acid binding; receptor; transcription factor
11	ASS1	Ligase
12	B2M	Defense/immunity protein
13	BCHE	None
14	BMP2	Signaling molecule
15	BMP7	Signaling molecule
16	BMPR1A	Kinase; receptor; transferase
17	BRAF	None
18	CA2	None
19	CASP1	Enzyme modulator; hydrolase; protease
20	CASP7	Enzyme modulator; hydrolase; protease
21	CASP8	Enzyme modulator; hydrolase; protease
22	CBR3	None
23	CBS	Hydrolase; isomerase; lyase
24	CD1A	None
25	CD44	None
26	CETP	None
27	CFTR	Transporter
28	CKB	Kinase; transferase
29	CMA1	Hydrolase; protease
30	COMT	Transferase
31	CRAT	Transferase
32	CSF2RB	Receptor
33	CSK	None
34	CTSB	Enzyme modulator; hydrolase; protease
35	CTSD	Hydrolase; protease
36	CTSG	Hydrolase; protease
37	DAPK1	Kinase; transferase
38	DPP4	Enzyme modulator; hydrolase; protease
39	EGFR	None
40	ELANE	Hydrolase; protease
41	ESR1	Nucleic acid binding; receptor; transcription factor
42	ESR2	Nucleic acid binding; receptor; transcription factor
43	ESRRA	Nucleic acid binding; receptor; transcription factor
44	F10	Hydrolase; protease
45	F2	Hydrolase; protease
46	F3	Defense/immunity protein; receptor
47	F7	Hydrolase; protease
48	F9	Hydrolase; protease
49	FGFR1	None
50	FGFR2	None
51	G6PD	Oxidoreductase
52	GAPDH	Oxidoreductase
53	GBA	None
54	GC	Transfer/carrier protein
55	GM2A	Transfer/carrier protein
56	GSK3B	Kinase; transferase
57	GSR	Oxidoreductase
58	GSTM1	None
59	GSTP1	None
60	GSTT1	None
61	HDAC4	None
62	HGF	Hydrolase; protease
63	HMGCR	None
64	HMOX1	Oxidoreductase
65	HRAS	Enzyme modulator
66	HSD17B1	Oxidoreductase
67	HSD17B4	None
68	HSP90AA1	Chaperone
69	IGF1R	None
70	IGFBP1	Enzyme modulator
71	IL10	None
72	IL1R1	Receptor
73	IL4	None
74	INS	None
75	INSR	None
76	ITGA1	None
77	JAK2	None
78	KCNAB2	Oxidoreductase; transporter
79	LCK	None
80	LDHB	Oxidoreductase
81	LGALS3	Cell adhesion molecule; signaling molecule
82	MAPK1	Kinase; transferase
83	MAPK10	Kinase; transferase
84	MAPK14	Kinase; transferase
85	MAPK8	Kinase; transferase
86	MDH2	Oxidoreductase
87	MIF	None
88	MME	Hydrolase; protease
89	MMP1	Hydrolase; protease
90	MMP3	Hydrolase; protease
91	MMP8	Hydrolase; protease
92	MTAP	Transferase
93	NCOA1	Transcription factor; transferase
94	NCOA2	Transcription factor; transferase
95	NNMT	Transferase
96	NOG	None
97	NOS2	None
98	NQO1	None
99	NR1H2	Nucleic acid binding; receptor; transcription factor
100	NR1H4	Nucleic acid binding; receptor; transcription factor
101	NR1I2	Nucleic acid binding; receptor; transcription factor
102	NR3C1	Nucleic acid binding; receptor; transcription factor
103	NR3C2	Nucleic acid binding; receptor; transcription factor
104	NR5A1	Transcription factor
105	NTRK1	None
106	NTRK2	None
107	OTC	None
108	PARP1	None
109	PDE4A	None
110	PDE4D	None
111	PGR	Nucleic acid binding; receptor; transcription factor
112	PKLR	None
113	PLAU	Hydrolase; protease
114	PLG	Hydrolase; protease
115	PNPO	Oxidoreductase
116	PON1	None
117	POR	None
118	PPARA	Nucleic acid binding; receptor; transcription factor
119	PPARD	Nucleic acid binding; receptor; transcription factor
120	PPARG	Nucleic acid binding; receptor; transcription factor
121	PPIB	None
122	PRDX2	Oxidoreductase
123	PRKACA	None
124	PROCR	Enzyme modulator; receptor
125	QDPR	Oxidoreductase
126	RBP4	Transfer/carrier protein
127	REN	Hydrolase; protease
128	RXRA	Nucleic acid binding; receptor; transcription factor
129	SEC14L2	None
130	SHBG	None
131	SLC9A3R1	None
132	SOD1	Oxidoreductase
133	SRC	None
134	STS	Hydrolase
135	SULT2A1	None
136	THRA	Nucleic acid binding; receptor; transcription factor
137	THRB	Nucleic acid binding; receptor; transcription factor
138	TNF	Signaling molecule
139	TPI1	Isomerase
140	TRAF2	Signaling molecule
141	TTPA	Transfer/carrier protein
142	TTR	Transfer/carrier protein; transporter
143	TYMP	Transferase
144	VDR	Nucleic acid binding; receptor; transcription factor