Hematological and plasma coagulation values of HVC1-treated male rats.
Test item (unit)
Treatment group (mg/kg/day)
Control
500
1,000
2,000
WBC (K/μL)
9.86 ± 1.77
9.01 ± 2.41
11.78 ±
11.71 ±
Neutrophil (K/μL)
1.64 ± 0.68
1.47 ± 0.42
1.92 ± 0.49
1.34 ± 0.38
Lymphocyte (K/μL)
7.83 ± 1.65
7.12 ± 2.05
9.35 ± 2.13
9.92 ± 2.82
Monocyte (K/μL)
0.21 ± 0.07
0.24 ± 0.08
0.29 ± 0.08
0.25 ± 0.10
Eosinophil (K/μL)
0.08 ± 0.03
0.07 ± 0.02
0.08 ± 0.03
0.07 ± 0.04
Basophil (K/μL)
0.00 ± 0.00
0.01 ± 0.01
0.01 ± 0.00
0.01 ± 0.01
LUC (K/μL)
0.10 ± 0.04
0.10 ± 0.04
0.14 ± 0.08
0.13 ± 0.06
NEP (%)
16.8 ± 6.2
16.8 ± 3.6
16.4 ± 3.9
11.5 ±
LYP (%)
79.2 ± 5.8
78.6 ± 3.3
79.2 ± 3.9
84.6 ±
MOP (%)
2.2 ± 0.9
2.6 ± 0.6
2.4 ± 0.5
2.1 ± 0.6
EOP (%)
0.8 ± 0.3
0.8 ± 0.3
0.7 ± 0.2
0.6 ± 0.3
BAP (%)
0.0 ± 0.1
0.1 ± 0.0
0.1 ± 0.0
0.1 ± 0.1
LUP (%)
1.0 ± 0.4
1.1 ± 0.4
1.2 ± 0.5
1.0 ± 0.3
RBC (K/μL)
8.81 ± 0.28
8.80 ± 0.44
8.72 ± 0.42
8.69 ± 0.43
Hemoglobin (g/dL)
15.6 ± 0.2
15.2 ± 0.6
15.2 ± 0.6
15.5 ± 0.8
Hematocrit (%)
45.1 ± 1.7
44.2 ± 1.8
44.1 ± 1.8
45.3 ± 2.7
MCV (fL)
51.3 ± 1.8
50.2 ± 1.7
50.6 ± 1.5
52.1 ± 1.6
MCH (pg)
17.8 ± 0.5
17.2 ±
17.4 ± 0.4
17.9 ± 0.5
MCHC (g/dL)
34.7 ± 1.0
34.3 ± 0.3
34.4 ± 0.5
34.3 ± 0.7
RDW (%)
12.8 ± 1.0
12.2 ± 0.9
12.6 ± 0.5
12.6 ± 0.5
Platelet (K/μL)
1068 ± 119
1015 ± 102
1111 ± 104
1108 ± 113
MPV (fL)
6.4 ± 1.3
6.6 ± 1.4
6.5 ± 1.4
6.5 ± 1.5
Reticulocyte (%)
2.05 ± 0.80
1.60 ± 0.59
1.85 ± 0.55
1.94 ± 0.33
PT (sec)
9.89 ± 0.71
9.60 ± 0.63
9.39 ± 0.21
9.40 ± 1.01
APTT (sec)
13.7 ± 2.7
16.0 ± 0.9
15.9 ± 1.3
15.7 ± 1.9
WBC: white blood cell; LUC: large unstained cell; NEP: percent of neutrophil; LYP: percent of lymphocyte; MOP: percent of monocyte; EOP: percent of eosinophil; BAP: percent of basophil; LUP: percent of large unstained cell; RBC: red blood cell; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; MPV: mean platelet volume; PT: prothrombin time; APTT: active partial thromboplastin time. Values are expressed as mean ± SD (n = 10). < 0.05, < 0.05 compared with the control group.
