Hematological and plasma coagulation values of HVC1-treated female rats.
Test item (unit)
Treatment group (mg/kg/day)
Control
500
1,000
2,000
WBC (K/μL)
5.47 ± 2.32
6.19 ± 2.46
5.94 ± 1.46
7.17 ± 3.34
Neutrophil (K/μL)
0.80 ± 0.37
0.79 ± 0.31
0.72 ± 0.15
0.87 ± 0.37
Lymphocyte (K/μL)
4.39 ± 2.03
5.10 ± 2.17
4.95 ± 1.42
5.97 ± 2.91
Monocyte (K/μL)
0.14 ± 0.07
0.15 ± 0.06
0.15 ± 0.10
0.16 ± 0.07
Eosinophil (K/μL)
0.08 ± 0.05
0.08 ± 0.04
0.07 ± 0.03
0.08 ± 0.05
Basophil (K/μL)
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
0.00 ± 0.00
LUC (K/μL)
0.06 ± 0.06
0.06 ± 0.04
0.05 ± 0.03
0.08 ± 0.05
NEP (%)
15.5 ± 7.2
13.3 ± 4.3
12.8 ± 4.6
12.6 ± 2.3
LYP (%)
79.3 ± 7.3
81.8 ± 4.4
82.6 ± 4.4
82.5 ± 3.6
MOP (%)
2.5 ± 0.7
2.5 ± 0.7
2.5 ± 1.1
2.3 ± 0.9
EOP (%)
1.6 ± 1.1
1.3 ± 0.6
1.2 ± 0.7
1.4 ± 1.3
BAP (%)
0.1 ± 0.1
0.1 ± 0.0
0.1 ± 0.1
0.1 ± 0.0
LUP (%)
1.1 ± 0.7
1.0 ± 0.4
0.8 ± 0.3
1.1 ± 0.3
RBC (K/μL)
7.85 ± 0.38
8.01 ± 0.39
7.78 ± 0.64
8.14 ± 0.32
Hemoglobin (g/dL)
14.7 ± 0.7
15.2 ± 0.7
14.9 ± 0.7
15.2 ± 0.6
Hematocrit (%)
43.3 ± 2.7
44.7 ± 2.7
43.3 ± 3.0
44.5 ± 0.9
MCV (fL)
55.2 ± 2.3
55.8 ± 1.9
55.7 ± 1.8
54.7 ± 1.4
MCH (pg)
18.8 ± 0.6
19.0 ± 0.5
19.2 ± 1.0
18.7 ± 0.4
MCHC (g/dL)
34.0 ± 1.1
34.0 ± 1.2
34.4 ± 1.6
34.1 ± 1.0
RDW (%)
11.5 ± 0.5
11.6 ± 0.4
11.6 ± 1.3
11.2 ± 0.4
Platelet (K/μL)
1097 ± 138
1038 ± 165
965 ± 367
1122 ± 131
MPV (fL)
8.6 ± 1.0
8.5 ± 0.7
8.9 ± 1.3
8.6 ± 0.7
Reticulocyte (%)
2.01 ± 0.26
2.03 ± 0.26
2.76 ± 2.31
1.90 ± 0.39
PT (sec)
8.78 ± 0.61
8.87 ± 0.47
8.84 ± 0.41
8.73 ± 0.53
APTT (sec)
14.9 ± 3.5
16.2 ± 1.3
15.1 ± 2.5
15.9 ± 1.2
WBC: white blood cell; LUC: large unstained cell; NEP: percent of neutrophil; LYP: percent of lymphocyte; MOP: percent of monocyte; EOP: percent of eosinophil; BAP: percent of basophil; LUP: percent of large unstained cell; RBC: red blood cell; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; MPV: mean platelet volume; PT: prothrombin time; APTT: active partial thromboplastin time. Values are expressed as mean ± SD (n = 10).
