Key CMM Combinations in Prescriptions for Treating Mastitis and Working Mechanism Analysis Based on Network Pharmacology

Table 4

Signal pathways related to mastitis disease and top affiliating genes of pathways.

Super pathways	Top Affiliating Genes
Innate Immune System	CCL5,CSF2,CXCL8,HP,ICAM1,IL17A
Akt Signaling	CCL5,CSF2,CXCL6,CXCL8,IL17A,IL6
Cytokine Signaling in Immune system	CCL5,CSF2,CXCL8,ICAM1,IL17A,IL6
Toll-Like receptor Signaling Pathways	CCL5,CP,CXCL8,IL6,NOD2,TLR2
Influenza A	CCL5,CXCL8,ICAM1,IL6,TLR2
Kaposi’s sarcoma-associated herpesvirus infection	CSF2,CXCL8,ICAM1,IL6,TLR2
Toll-like receptor signaling pathway	CCL5,CXCL8,IL6,LBP,TLR2
Selenium Micronutrient Network	ALB,CCL5,ICAM1,IL6
IL-17 Family Signaling Pathways	CSF2,CXCL6,CXCL8,IL17A,IL6,TLR2
Tuberculosis	IL6,LBP,NOD2,TLR2
Bacterial infections in CF airways	CXCL8,IL6,LBP,TLR2
Interleukin-4 and 13 signaling	CXCL8,ICAM1,IL17A,IL6,LBP
IL27-mediated signaling events	IL17A,IL6,TLR2
TNF signaling pathway	CCL5,CSF2,ICAM1,IL6,NOD2
AGE-RAGE signaling pathway in diabetic complications	CXCL8,ICAM1,IL6
Amoebiasis	CSF2,CXCL8,IL6,TLR2
NF-kappa B signaling pathway	CXCL8,ICAM1,LBP
Th17 Differentiation Pathway	IL17A,IL6,TLR2
Salmonella infection	CSF2,CXCL8,IL6,LBP
Pertussis	CXCL6,CXCL8,IL6
IgA-Producing B Cells in the Intestine	ICAM1,IL6,TLR2
Lung fibrosis	CCL5,CSF2,CXCL8,IL6
Photodynamic therapy-induced NF-kB survival signaling	CSF2,CXCL8,ICAM1,IL6
Glucocorticoid receptor regulatory network	CSF2,CSN2,CXCL8,ICAM1,IL6
Legionellosis	CXCL8,IL6,TLR2
Cytokine production by Th17 cells in CF	CSF2,CXCL6,CXCL8,ICAM1,IL17A,IL6
Malaria	CXCL8,ICAM1,IL6,TLR2
amb2 Integrin signaling	HP,ICAM1,IL6
Interleukin-10 signaling	CCL5,CSF2,CXCL8,ICAM1,IL6
Rheumatoid arthritis	CCL5,CSF2,CXCL6,CXCL8,ICAM1,IL17A
G-protein signaling_RhoB regulation pathway	CCL5,CSF2,CXCL6,CXCL8,IL17A,IL6
G-protein signaling_Rap2B regulation pathway	CCL5,CSF2,CXCL6,CXCL8,IL17A,IL6