Key CMM Combinations in Prescriptions for Treating Mastitis and Working Mechanism Analysis Based on Network Pharmacology

Table 6

“Drug combination-target-disease” related to “breast” and “mastitis”.

No	key CMM combination	Target related diseases	Drug target
1	Taraxaci herba, semen citri reticulatae, Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma	Inflammation	ADORA1;ADORA2A;PLA2G1B;PLD1;
		Breast Cancer	CYP19A1;ESR1;PGR;VDR;
		Inflammatory Diseases	ADORA1;CNR1;
		Breast Cancer (Hormone-Sensitive)	HSD17B1;
2	Taraxaci herba, Salvia miltiorrhiza Bunge, Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma	Breast Cancer	CYP19A1;ESR1;PGR;VDR;
		Inflammation	ADORA1;ADORA2A;PLA2G1B;PLD1;
		Inflammatory Diseases	PIK3CD;
		Breast Cancer (Hormone-Sensitive)	HSD17B1;
3	Taraxaci herba, Radix Salviae miltiorrhizae, Paeoniae Radix Alba and Glycyrrhizae Radix et Rhizoma	Inflammation	ADK;ADORA1;ADORA2A;PLA2G1B;PLD1;PTGS2;
		Breast Cancer	CYP19A1;ESR1;PGR;PTGS2;VDR;
		Breast Cancer (Hormone-Sensitive)	HSD17B1;
4	Taraxaci herba, Semen Coicis and Vigna angularis	Breast cancer	ESR1;PGR;VDR;
		Inflammation	PLD1;
5	Taraxaci herba, Semen Coicis and Vigna angularis	Inflammation	ADK;PLA2G1B;PLD1;PTGS2;
		Inflammatory diseases	PTGS2;
		Breast cancer	ESR1;PGR;PTGS2;VDR;
6	Taraxaci herba,herba houttuyniae and pericarpium trichosanthis kirilowii et multilobae	Inflammation	ADK;ADORA1;PLA2G1B;PLD1;PTGS2;
		Breast cancer	ESR1;PGR;PTGS2;VDR;
		Inflammatory diseases	PTGS2;
7	Taraxaci herba, trichosanthes kirilowii peel and Semen Coicis	Inflammation	ADORA1;PLD1;
		Breast cancer	ESR1;PGR;VDR;
8	Taraxaci herba, trichosanthes kirilowii peel and Semen Coicis	Inflammation	ADK;ADORA1;ADORA2A;PLA2G1B;PTGS2;
		Breast cancer	CYP19A1;ESR1;PGR;PTGS2;VDR;
		Breast cancer (hormone-sensitive)	HSD17B1;
		Inflammatory diseases	PIK3CD;PTGS2;
9	Paeoniae Radix Alba, Bupleuri Radix and Glycyrrhizae Radix et Rhizoma	Inflammation	ADORA1;ADORA2A;PLA2G1B;PPARD;PPARG;PTGS2;
		Breast cancer	AKT1;CYP19A1;ESR1;PGR;PTGS2;VDR;
		Breast cancer (hormone-sensitive)	HSD17B1;
		Inflammatory diseases	PIK3CD;PTGS2;
10	semen citri reticulatae, pericarpium citri reticulatae viride and Bupleuri Radix	Inflammation	ADORA1;ADORA2A;PLA2G1B;PPARD;PPARG;PTGS2;
		Breast cancer	AKT1;CYP19A1;ESR1;PGR;PTGS2;VDR;
		Inflammatory diseases	PIK3CD;PTGS2;
11	Taraxaci herba and Viola philippica	Breast cancer	ESR1;PGR;VDR;
		Inflammation	PLA2G1B;PLD1;
12	Taraxaci herba and Lamiophlomis rotata Kudo	Breast cancer	ESR1;PGR;VDR;
		Inflammation	PLD1;