Safety Concerns of Traditional Chinese Medicine Injections Used in Chinese Children
Table 3
The ADR reports of the paediatric and adult population treated with 16 types of TCM injections.
TCM injections
ADR Reports
Chi-squared test
Children (%)
Adult (%)
Shegankangbingdu herbal injection
1 (0.3)
1 (0.3)
P<0.000
Shuanghuanglian herbal injection
18 (5.7)
46 (14.5)
Compound shexiang herbal injection
2 (0.6)
1 (0.3)
Qingkailing herbal injection
14 (4.4)
42 (13.2)
Zhongjiefeng herbal injection
1 (0.3)
0 (0.0)
Huangqi herbal Injection
1 (0.3)
28 (8.8)
Dengzhanxixin herbal injection
1 (0.3)
3 (0.9)
Chaihu herbal injection
3 (0.9)
1 (0.3)
Banlangen herbal injection
1 (0.3)
0 (0.0)
Shenmai herbal injection
1 (0.3)
34 (10.7)
Yuxingcao herbal injection
15 (4.7)
37 (11.7)
Xiyanping herbal injection
10 (3.2)
6 (1.9)
Yujin herbal injection
3 (0.9)
1 (0.3)
Reduning herbal injection
5 (1.6)
4 (1.3)
Tanreqing herbal injection
2 (0.6)
17 (5.4)
Danshen herbal injection
2 (0.6)
16 (5.0)
Total
80 (25.2)
237 (74.8)
Proportion of ADR reports of each drug was calculated by using the total number of ADRs of all drug as denominators. The Pearson Chi-squared test must meet two criteria: (i) all expected frequency values (T)≥1, and (ii) the proportion of T (1≤T<5) does not exceed 20%. In our study, the proportion of T (T<5) was 56.3%, and the minimum T was 0.25; thus, Fisher’s precise inspection (Monte Carlo method) was used to analyse the data. Differences with P<0.05 were deemed statistically significant. TCM: traditional Chinese medicine, ADR: adverse drug reaction
