Subcutaneous Injection of Myrrh Essential Oil in Mice: Acute and Subacute Toxicity Study

Table 4

Effect on the activity of liver and kidney enzymes. The blood samples of different group of mice were checked for the liver and kidney enzymes to evaluate the liver and kidney toxicity due to MEO injection in different doses. For the liver toxicity, the levels of AST and ALT enzymes were analyzed. Similarly for the kidney toxicity, the levels of BUN and CRE were analyzed.

Group	AST (U/L)	ALT (U/L)	BUN (U/L)	CRE (U/L)
Control	131.2±3.3	34.0±1.3	21.0±2.1	0.05±0.02
MEO 20	141.7±4.2	27.3±2.1	16.7±1.7	0.14±0.03
MEO 40	140.0±3.7	28.5±1.7	15.4±2.5	0.19±0.02
MEO 80	177.5±4.1	21.3±2.3	11.0±1.8	0.18±0.07
F-200	129.5±2.0	32.5±3.2	20.3±2.0	0.07±0.01

Values are expressed as mean ± standard deviation (n = 6). Statistical significance was calculated using one-way ANOVA followed by Dunnett’s multiple comparisons test. < 0.05 vs control.