BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling

Figure 4

BRM270 restrains CD44⁺ PDAC cells derived tumor growth via downregulating Sonic hedgehog signaling pathway. (a) Sizes of tumors with and without 5 mg/kg BRM270 treatment after 35-day inoculation. (b) Weights of tumors with and without 5 mg/kg BRM270 treatment. (c) Western blotting of epithelial-mesenchymal transition (EMT) genes in lysates treated with and without BRM270 50 μg/mL. (d) Western blotting of signaling pathways in lysates treated with and without BRM270 50 μg/mL. Significant differences of values are compared to values of groups treated and nontreated with BRM270 and marked as follows: P< 0.05; P< 0.01; P< 0.0001.

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