Effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs on Platelet Aggregation Rate and PI3K/Akt Pathway in the Rat Model of Coronary Heart Disease

Table 1

FSAMB inhibited ADP-induced platelet aggregation in vitro and vivo. ^※Platelet aggregation rate is abbreviated as PAR which is intervened by ADP 10umol/L. Mean ± SD. n = 8.P<0.05 and P<0.01 versus the model control group. P<0.05 and P<0.01 versus drug control.

Group	n	PAR	PAR	LDH	CK-MB	cTnI
		In vitro (%)	In vivo (%)	(U/L)	(U/L)	(ng/mL)
Normal control; (NaCl 0.15mol/L)	8	59.99±4.45	48.41±4.16	309±26	3.49±0.56	2.93±0.38
Model control; (ADP10umol/L)	8	73.14±4.13	61.23±5.38	1923±327	15.83±3.68	13.55±2.67
FSAMB; (168mg/kg)	8	58.75±3.92	50.05±4.50	1800±318	14.38±2.16	13.25±2.27
FSAMB; (336mg/kg)	8	57.21±3.26	33.60±3.24	1684±283	12.1±3.23	12.09±2.13
FSAMB; (672mg/kg)	8	50.99±2.93	22.90±3.12	1317±169	11.37±1.61	11.06±2.1
Drug Control	8	61.84±5.26; (aspirin)	20.81±1.55; (clopidogrel)	1155±280	11.42±2.11	12.03±1.93