Comparative Pharmacokinetic Study of Taxifolin after Oral Administration of Fructus Polygoni Orientalis Extract in Normal and Fibrotic Rats by UPLC-MS/MS

Table 6

Main pharmacokinetic parameters of taxifolin in rats determined after oral administration of 1.23 g/kg FPO extract (n = 3, mean ± SD).

Parameters	Unit	Normal group	Model group	value
t1/2	h	14.66 ± 5.11	9.77 ± 4.19	0.269
Tmax	h	0.44 ± 0.096	0.33 ± 0	0.116
Cmax	ng/mL	1940 ± 502.2	2648 ± 208.5	0.044^#
AUC(0⟶t)	h·ng/mL	4949.7 ± 764.89	6679.9 ± 734.26	0.048^#
AUC(0⟶∞)	h·ng/mL	5049.4 ± 760.7	7095.2 ± 962.3	0.045^#
F	%	5.778 ± 4.01	5.64 ± 2.77	0.963
Vz	mL/kg	73912 ± 45956.3	48327 ± 15259.3	0.428
Cl	mL/h	3382.4 ± 740.8	3538 ± 533.7	0.856
Ke	1/h	0.0524 ± 0.0219	0.0799 ± 0.0321	0.287
AUCINF_pred	h·ng/mL	4513 ± 1580.7	7073.7 ± 947.6	0.074
MRTlast	h	2.46 ± 0.412	3.17 ± 0.039	0.04^#